Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward.

ABSTRACT:

Background

Women tend to progress from initial alcohol use to dependence more rapidly than men, a phenomenon known as the "telescoping effect". This suggests different consequences of early alcohol use, which can impact the development of an Alcohol Use Disorder (AUD). Previous evidence demonstrated that nucleus accumbens core (NAcC) chemogenetic manipulations resulted in opposite effects on binge-like drinking [stimulation decreased ethanol intake in C57BL/6J (B6) females, while inhibition decreased intake in males]. In humans, ethanol cue conditioning is linked to the positive subjective effects of alcohol intake and intoxication. We tested the hypothesis that chemogenetic manipulation of NAcC activity alters ethanol reward (measured by conditioned place preference, CPP) in a sex

SUBMITTER: Chan AE 

PROVIDER: S-EPMC12392586 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature