Cis-regulation analysis of RNA m6A methylation and gene expression in colorectal cancer.

ABSTRACT: RNA N6-methyladenosine (m6A) methylation is a major epigenetic modification that plays a critical role in regulating gene expression in tumors. Although the regulation of individual genes by m6A methylation has been extensively studied, a systematic quantification of transcriptome-wide associations between RNA methylation and gene expression remains limited. In this study, we analyzed publicly available MeRIP-seq and RNA-seq datasets of paired colorectal cancer (CRC) and adjacent normal tissues from four patients, proposing a statistical model to quantify the cis-regulation between m6A methylation and gene expression in CRC. The results indicated that (1) A total of 46,500 and 31,715 unique m6A peaks were identified in CRC and normal control (NC) tissues, respectively. Compared with NC tis

SUBMITTER: Lin ZL 

PROVIDER: S-EPMC12392630 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature