A T cell-based ubiquitin-mediated mRNA vaccine provides cross-protection against H1N1 and B influenza viruses in mice.

ABSTRACT: Given the persistent antigenic drift of seasonal influenza viruses and the continuous threat of emerging pandemics, there is an urgent necessity to develop novel influenza vaccines capable of conferring broad-spectrum immunity against multiple viral subtypes. CD8⁺ T cells provide a promising approach to achieving such protection because of their ability to recognize conserved internal antigens. Particularly, the highly cross-reactive internal nucleoprotein of influenza virus demonstrates remarkable efficacy in safeguarding against infection caused by diverse strains. Ubiquitination modification is critical for the differentiation and functionality of CD8⁺ T cells, thereby modulating the immune response. In this study, three mRNA vaccines were designed using the influe

SUBMITTER: Di Y 

PROVIDER: S-EPMC12392679 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature