Biodegradable, Biocompatible, and Crosslinkable Polymers Enable Biosafe and Sustainable Soft Gels and Nanogels for Biomedical Applications.

ABSTRACT: To date, more biodegradable polymers have been developed due to the growing recognition of the advantages of biodegradable and biocompatible polymers for biomedical applications. In this study, we introduce the synthesis and characterization of innovative polymers that incorporate biodegradable backbones composed of trimethylolpropane and adipic acid moieties and biocleavable side chains containing pyridyl disulfide groups. Notably, their synthesis is straightforward and catalyst-free under ambient conditions, minimizing potential toxicity and immune responses caused by catalyst residues in polymer materials. The new polymers have desired molecular weight (Mn: 18.8 kDa) with a narrow dispersion (PDI: 1.32) and offer complete biodegradability, biocompatibility, crosslinking capabilities, an

SUBMITTER: Sui B 

PROVIDER: S-EPMC12392724 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature