<i>CHP2</i> Modifies Chronic <i>Pseudomonas aeruginosa</i> Airway Infection Risk in Cystic Fibrosis.

ABSTRACT: Rationale: Chronic Pseudomonas aeruginosa (Pa) airway infection is common and a key contributor to diminished lung function and early mortality in persons with cystic fibrosis (PwCF). Risk factors for chronic Pa among PwCF include CFTR (cystic fibrosis transmembrane conductance regulator) genotype, genetic modifiers, and environmental factors. Intensive antibiotic therapy and highly effective modulators do not eradicate Pa in most adolescents and adults with cystic fibrosis. Objectives: To identify new genetic modifiers contributing to the pathophysiology of chronic Pa infection in PwCF. Methods: A total of 4,945 participants in the CF Genome Project with whole-genome sequencing linked to longitudinal clinical data from the 201

SUBMITTER: Faino AV 

PROVIDER: S-EPMC12392791 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature