Unilateral focused ultrasound thalamotomy for tremor-dominant Parkinson's disease: blinded evaluation and imaging correlation.

ABSTRACT: There have been promising outcomes from the use of unilateral High-intensity focused ultrasound (HiFUS) thalamotomy in tremor-dominant Parkinson's disease. However, the reliability of this treatment has been questioned due to the high rate of tremor relapse. Authors have hypothesized that treatment failure is due to insufficient HiFUS lesion size, though detailed volumetric lesion analyses are lacking. To report the blinded tremor outcomes of unilateral HiFUS thalamotomy in tremor-dominant Parkinson's disease and correlate these outcomes with lesion characteristics, including the dentatorubrothalamic tract ablation overlap, which may provide valuable insights into the mechanisms behind tremor relapse and ultimately refine the optimal HiFUS target for tremor in Parkinson's disease. Retrospe

SUBMITTER: Peters J 

PROVIDER: S-EPMC12392903 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature