RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy-mediated degradation of the viral silencing suppressor P6 protein.

ABSTRACT: Responsive to desiccation 21 (RD21) is a papain-like cysteine protease (PLCP). PLCPs are involved in plant growth and development, as well as stress and plant immune responses. Currently, few studies have reported on the involvement of PLCPs in defence against viral infections. Here, we show that RD21 of strawberry (Fragaria vesca) interacts with the strawberry vein banding virus (SVBV) P6 protein. SVBV infection induces FvRD21 expression. Subcellular localization revealed that FvRD21 and P6 colocalize in the perinuclear and cytoplasmic regions. Further analysis showed that FvRD21 overexpression induces the autophagy pathway that degrades the P6 protein, destroys the function of P6 as a viral suppressor of RNA silencing (VSR), inhibits the pathogenicity of P6, and confers resistance to SVB

SUBMITTER: Yang X 

PROVIDER: S-EPMC12392972 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature