Active Armoring of Protocell Condensates with Metal-Phenolic Networks.

ABSTRACT: This study presents the use of metal-phenolic networks (MPNs) for the removable membranization of peptide-based condensates, providing a powerful strategy for stabilizing and protecting condensates from chemically harmful agents. It is demonstrated that the redox-active properties of MPNs allow for controlled membrane formation and disassembly, offering tunable regulation of membrane thickness and permeability. Using ferric ion (Fe³⁺) and tannic acid, poly-L-lysine and adenosine triphosphate condensates are successfully coated with MPN membranes, which significantly enhances their structural stability and resistance to fusion. Additionally, it is observed that when exposed to Tris(2-carboxyethyl)phosphine (TCEP), a reducing agent, the MPN membrane acts as a sacrificial layer, pr

SUBMITTER: Lee JH 

PROVIDER: S-EPMC12393011 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature