Plasmonic Mesoporous Gold-Based SERS Biosensor for Ovarian Cancer-Derived Extracellular Vesicles.

ABSTRACT: Extracellular vesicles (EVs) are lipids bilayer-delimited particles carrying bioactive molecules such as proteins, lipids, and nucleic acids, reflecting the physiological state of their origin. Found in biofluids like saliva, urine, blood, and peritoneal fluid, EVs serve as promising minimally invasive biomarkers for several conditions including cancer. However, achieving high sensitivity and specificity in EV detection remains technically challenging. Placental Alkaline Phosphatase (PLAP), an enzyme primarily expressed in the placenta during pregnancy, has emerged as a clinically relevant biomarker in gynecological malignancies, including ovarian cancer (OC). In this study, a nanoengineered mesoporous gold (mAu)-based Surface-Enhanced Raman Spectroscopy (SERS) platform is reported for the

SUBMITTER: Bashir J 

PROVIDER: S-EPMC12393012 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature