A programmable modular robot for the synthesis of molecular machines.

ABSTRACT: The assembly of molecular nanomachines using atomically precise manipulations promises to enable nanotechnology with unprecedented architectural features and exquisite functional properties. However, this future is critically limited by the ability to autonomously manufacture nanomachines, with current efforts being heavily labor intensive. A system is needed to program and assemble matter under digital control, unifying molecular nanotechnology and macroscale chemical processes. Herein, we present a universal chemical robotic synthesis platform (Chemputer) that produces functional molecular machines. By integrating autonomous feedback through on-line NMR and liquid chromatography, a divergent four-step synthesis and purification of molecular rotaxane architectures are achieved. The synthe

SUBMITTER: Rauschen R 

PROVIDER: S-EPMC12393038 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature