Copper-catalysed dehydrogenation or lactonization of C(sp³)-H bonds.

ABSTRACT: Cytochrome P450 enzymes are known to catalyse bimodal oxidation of aliphatic acids via radical intermediates, which partition between pathways of hydroxylation and desaturation^1,2. Developing analogous catalytic systems for remote C-H functionalization remains a significant challenge^3-5. Here, we report the development of Cu(I)-catalysed bimodal dehydrogenation/lactonization reactions of synthetically common N-methoxyamides through radical abstractions of the γ-aliphatic C-H bonds. The feasibility of switching from dehydrogenation to lactonization is also demonstrated by altering reaction conditions. The use of a readily available amide as both radical precursor and internal oxidant allows for the development of redox-neutral C-H functionalization reactions with metha

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12393039 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature