Chemokine Receptor Profiles as Predictors of Survival and Early Progression in Follicular Lymphoma.

ABSTRACT: Objective: Classical follicular lymphoma (FL) is a heterogeneous malignancy. Early progression within 24 months (POD24) is linked to poor outcomes. However, precise risk stratification remains unclear. We aimed to explore chemokine receptor (CR) expression profiles as potential markers of disease biology and outcome in FL. Methods: We analyzed mRNA expression of CCR1-CCR10, CXCR1-CXCR5, CX3CR1, and XCR1 in 52 FL samples (13 POD24, 39 non-POD24) using RT-qPCR. Immunohistochemistry for CCR3, CCR7, CXCR3, CXCR4, and CXCR5 was performed. Reactive tonsils (n = 5) served as controls. Results: Compared to controls, FL samples showed lower CCR1, CCR6, CCR7, CXCR1, CXCR5, and CX3CR1 but higher <

SUBMITTER: Zupo A 

PROVIDER: S-EPMC12393056 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature