From critical care to organ preservation: the potential role of hemadsorption in transplantation-a narrative review.

ABSTRACT:

Background and objective

Hemadsorption, a therapeutic modality traditionally used to mitigate cytokine storm in critically ill patients and is now being tested in other medical fields including organ transplantation, especially for organs from extended criteria donors. Such organs are susceptible to ischemia-reperfusion injury (IRI) during transplantation, which is known to release a cascade of innate immune mediators including damage-associated molecular patterns (DAMPs) and cytokines during reperfusion and ultimately leading to graft dysfunction based on the metabolic injury. To address this challenge, early studies have integrated hemadsorption filters into organ perfusion circuits, such as normothermic regional perfusion (NRP) in donors and ex-situ machine perfusion (MP)

SUBMITTER: Jiao C 

PROVIDER: S-EPMC12393119 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature