Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma: survival outcomes and prognostic factors from a systematic review and meta-analysis.

ABSTRACT:

Background

Advanced hepatocellular carcinoma (HCC) poses significant treatment challenges, with limited options and poor prognosis. Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising therapy, potentially offering superior outcomes compared to transarterial chemoembolization (TACE). This study aimed to systematically compare the survival outcomes and safety profiles of HAIC versus TACE in patients with advanced HCC, and to identify key prognostic factors influencing treatment efficacy to guide personalized therapeutic strategies.

Methods

This meta-analysis included 14 studies assessing survival outcomes and safety profiles of HAIC versus TACE in advanced HCC. Overall survival (OS), progression-free survival (PFS), and adverse events were analyzed. Subgro

SUBMITTER: Zeng D 

PROVIDER: S-EPMC12393126 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature