The risk of hepatocellular carcinoma recurrence after liver transplantation increases with locoregional therapies in patients initially within Milan criteria.

ABSTRACT:

Background

The optimal timing of transplantation for hepatocellular carcinoma (HCC) is still under debate regarding the tumor biology and locoregional control with various treatments. We designed this study to find out what kind of factors affect the post-transplantation outcome focusing on the timing of transplantation.

Methods

We analyzed HCC patients who met the Milan criteria at the initial stage and subsequently underwent liver transplantation (LT) between 2007 and 2020. We examined the number of locoregional therapies (LRTs) received, as well as data on tumor recurrence and survival. The number of LRTs was categorized into four groups: none, one or two, three or four, and five or more. Both recurrence-free survival and overall survival were analyzed.

Results

A t

SUBMITTER: Rhu J 

PROVIDER: S-EPMC12393127 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature