Radial multi-echo bSSFP and IDEAL chemical shift separation in k-space for high-speed 3D hyperpolarized ¹³C metabolic MRI.

ABSTRACT:

Purpose

Hyperpolarized (HP) carbon-13 (¹³C) MRSI provides real-time information about metabolic processes but lacks high temporal and spatial resolution. This study introduces a multi-echo-balanced steady-state free precession (ME-bSSFP) method with a 3D radial readout trajectory in a spiral phyllotaxis pattern as a method for non-Cartesian HP ¹³C MRSI that allows for flexible reconstruction with high spatiotemporal resolution.

Methods

The approach uses ME-bSSFP with iterative decomposition of echo asymmetry and least-squares estimation (IDEAL) for separating ¹³C metabolite signals. The method was evaluated using thermally polarized ¹³C-enriched phantoms and in vivo experiments in healthy rats injected with HP [1-¹³C]pyr

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12393183 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature