Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions.

ABSTRACT:

Purpose

Monte Carlo simulations and short diffusion time measurements have suggested neurite beading and swelling as the underlying mechanism of reduced diffusion in acute stroke, although the observed diffusion time dependence is often heterogeneous and not yet fully understood. This study aimed to investigate the heterogeneity of diffusion time effects in ischemic lesions and explore the potential microstructural basis with Monte Carlo simulations.

Methods

Pulsed gradient spin echo (PGSE, diffusion time 40 ms) and oscillating gradient spin echo (OGSE 40 Hz, diffusion time ˜5.1 ms) were acquired within 5 min in 39 acute ischemic stroke patients at 3 T. Mean, axial, and radial diffusivity differences between OGSE and PGSE (ΔMD/ΔAD/ΔRD) were compared between lesion and contra

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12393189 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature