Development of an echo-shifted, multi-echo, gradient-echo sequence for T₂* quantification of slow-relaxing water pools.

ABSTRACT:

Purpose

Although conventional multi-echo gradient-echo (GRE) sequences effectively quantify short and intermediate T₂* in brain tissue, and general interest in cerebrospinal fluid (CSF) is growing due to its association with the glymphatic system, quantifying T₂* in CSF remains underexplored. Accurate quantification of the slow-relaxing water pools requires imaging at long echo times, significantly increasing acquisition time. This study proposes a novel sequence capable of quantifying the entire range of T₂* without prolonged acquisition time, mapping T₂* in both CSF and brain tissue.

Methods

The proposed echo-shifted, multi-echo GRE (ES-mGRE) combines the conventional multi-echo GRE sequence with an echo-shifting technique. Addit

SUBMITTER: Shin S 

PROVIDER: S-EPMC12393191 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature