3D-printable phantoms for quantitative dynamic contrast-enhanced MRI.

ABSTRACT:

Purpose

A novel 3D-printed phantom design and methodology are proposed, addressing important requirements for technical validation, quality assurance, and multi-site harmonization of quantitative DCE-MRI measurements.

Methods

Phantoms were produced by 3D-printing (3DP) gels incorporating channels and pores as proxies for blood vessels and extravascular extracellular space, respectively. A flow circuit was designed to reproduce clinically relevant arterial input functions. Using nine gels with variable porosity and channel size, we evaluated the effect of 3DP parameters on DCE-MRI parameters obtained using the extended Tofts model (ET). Physical gel and fitted model parameters were correlated by multiple linear regression.

Results

All phantoms generated realistic arter

SUBMITTER: Sarwar MS 

PROVIDER: S-EPMC12393202 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature