Cardiac diffusion kurtosis imaging in the human heart in vivo using 300 mT/m gradients.

ABSTRACT:

Purpose

Diffusion tensor imaging (DTI) is commonly used in cardiac diffusion magnetic resonance imaging (dMRI). However, the tissue's microstructure (cells, membranes, etc.) restricts the movement of the water molecules, making the spin displacements deviate from Gaussian behavior. This effect may be observed with diffusion kurtosis imaging (DKI) using sufficiently high b-values ( b>450s/mm2$$ \mathrm{b}>450\kern0.2em \mathrm{s}/{\mathrm{mm}}^2 $$ ), which are presently outside the realm of routine cardiac dMRI due to the limited gradient strength of clinical scanners. The Connectom scanner with Gmax=300mT/m$$ {\mathrm{G}}_{\mathrm{max}}=300\kern0.2em \mathrm{mT}/\mathrm{m} $$ enables high b-values at echo times (TE) similar to DTI on standard clinical scanners, therefore facilitat

SUBMITTER: Afzali M 

PROVIDER: S-EPMC12393209 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature