High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography.

ABSTRACT: DNA origami information storage is a promising alternative to silicon-based data storage, offering a secure molecular cryptography technique that conceals information within arbitrarily folded DNA origami nanostructures. Routing, sliding, and interlacing staple strands lead to the creation of a large 700-bit key size. The realization of practical DNA data storage requires high information density, robust security, and accurate and rapid information retrieval. To meet these requirements, advanced readout techniques and large encryption key sizes are essential. In this study, we report an enhanced DNA origami cryptography protocol to encrypt information in 2D and 3D DNA origami structures, increasing the number of possible scaffold routings and increasing the encryption key size. We employed

SUBMITTER: Wisna GBM 

PROVIDER: S-EPMC12393260 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature