Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain.

ABSTRACT: Brain aging is a major risk for neurodegeneration, yet the underlying molecular mechanisms remain poorly understood. Here we performed an integrative proteo-transcriptomic analysis of the aging mouse brain, uncovering molecular signatures of aging through the assessment of protein aggregation, mRNA relocalization, and comparative proteomics across eight models of premature aging and neurodegeneration. We identified dynamic changes in physiological aging highlighting differences in synaptic maintenance and energy-allocation. These were linked to changes associated with fundamental protein biochemical properties such as size and net charge. Network analysis highlighted a decrease in mitochondrial complex I proteins not compensated at the mRNA level. Aggregation of 60S ribosome subunits indic

SUBMITTER: Hemandhar-Kumar N 

PROVIDER: S-EPMC12393264 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature