Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity.

ABSTRACT: Autosomal monoallelic gene expression and asynchronous replication between alleles are well-established features of imprinted genes and genes regulated by allelic exclusion. Inactivation/Stability Centers (I/SCs) are recently described autosomal loci that exhibit epigenetic regulation of allelic expression and replication timing, with differences that can be comparable to those observed between the active and inactive X chromosomes ¹. Here we characterize hundreds of autosomal loci with allele-specific epigenetic regulation of replication timing and gene expression, defining them as I/SCs. I/SCs are approximately 1 megabase in size and can contain both protein-coding and noncoding genes. In different single cell derived clones, these genes may be expressed from a single allele,

SUBMITTER: Heskett MB 

PROVIDER: S-EPMC12393279 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature