Constructing and Using Cell Type Populations of the Human Reference Atlas.

ABSTRACT: The human body contains ~27-36 trillion cells of up to 10,000 cell types (CTs) within a volume of ~62-120 liters (males) and 52-89 liters (females). The Human Reference Atlas (HRA) v2.3 provides a quantitative 3D framework of CTs across 73 reference organs and 1,283 3D anatomical structures (ASs). The HRA Cell Type Population (HRApop) effort quantifies CTs per AS using high-quality single-cell (sc) data processed through scalable, reproducible workflows and cell type annotation (CTann) tools. HRApop v1.0 includes reference CT populations for 73 ASs (112 when sex-specific) using 662 datasets spatially registered to 230 locations across 17 organs (31 when sex-specific). For 558 sc-transcriptomics datasets (11,042,750 cells), CTs and biomarker expression were computed using Azimuth, CellTypis

SUBMITTER: Bueckle A 

PROVIDER: S-EPMC12393406 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature