Closed-Loop Connectivity Best Supports Angular Tuning and Sleep Dynamics in a Biophysical Thalamocortical Circuit Model.

ABSTRACT: Despite recent advancements in mapping thalamic and cortical projections, the specific organization of intrathalamic and corticothalamic connectivity remains elusive. Current experimental approaches cannot definitively determine whether these connections are arranged in reciprocal (closed-) or non-reciprocal (open-loop) circuits. We developed a biophysically detailed multi-compartmental model of the mouse whisker pathway, built on anatomical and physiological data. We showed that closed-loop intrathalamic projections between the thalamocortical (TC) relay neurons in the ventral posteromedial nucleus and the inhibitory neurons in the thalamic reticular nucleus (TRN) best reproduce thalamic spiking and local field potential responses across awake and sleep states. Increasing the percentage o

SUBMITTER: Moreira JV 

PROVIDER: S-EPMC12393421 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature