Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.

ABSTRACT: The free fatty acid receptor FFAR4 is expressed in pancreatic islets, and its activation potentiates insulin and inhibits somatostatin (SST) secretion. We investigated the mechanisms of action of FFAR4 on hormone secretion in mouse and human islets. The effects of the FFAR4 agonist Compound A (Cpd A) on insulin and SST secretion were investigated in islets from mice following ablation of δ cells, deletion of SST and deletion of the G protein Gα_z (Gnaz ^-/-), in purified mouse β and δ cells, in human EndoC-bH5 cells, and in human islets. Ca⁺⁺ dynamics in response to Cpd A were measured in δ cells from Gnaz ^-/- mouse islets and in human islets. The insulinotropic effect of Cpd A was lost in δ cell-ablated and SST-deficient mouse islets

SUBMITTER: Reininger L 

PROVIDER: S-EPMC12393430 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature