CCL26 and CXCL12 Promote Release of Insulin-Sensitizing Adipose Tissue Macrophage sEVs from Subcutaneous Adipose Tissue in Obesity.

ABSTRACT: Unlike visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) can play a protective role against the development of insulin resistance and metabolic dysfunction in obesity. Here, we show that, in obesity, subcutaneous adipose tissue macrophages (ATMs) release small extracellular vesicles (sEVs) that can improve insulin sensitivity, opposite to the effect of visceral ATM sEVs. This functional difference was associated with an increase in the proportion of insulin-sensitizing, resident ATMs in SAT. In vivo and in vitro measurements of ATM growth and trafficking combined with single cell RNA sequencing (scRNA-seq) revealed that higher resident ATM survival and lower blood monocyte immigration along with decreased transition to pro-inflammatory ATMs collectively lead to

SUBMITTER: Jeelani I 

PROVIDER: S-EPMC12393446 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature