Tissue-Specific Distribution of Eggs in The Definitive Host Drives Transcriptomic and Behavioral Differences in <i>Schistosoma Mansoni</i> Miracidia.

ABSTRACT: Schistosomiasis is a neglected tropical disease caused by human-infective schistosomes (Trematoda: Schistosoma). Intestinal schistosomiasis in sub-Saharan Africa and the Neotropics is caused primarily by Schistosoma mansoni and is transmitted by several Biomphalaria planorbid snail species. Adult male and female parasites in the definitive mammalian host pair and reside in the mesenteric vasculature; females lay eggs that traverse the intestinal wall to be excreted, but a significant proportion become trapped in host tissues, especially the liver, eliciting granulomatous immune responses that underlie most disease pathology. S. mansoni is the primary lab model for research and, due to the abundance and ease of harvesting, liver-derived eggs are almost exclusivel

SUBMITTER: Willett S 

PROVIDER: S-EPMC12393456 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature