Reelin Controls the Directional Orientation, Apical Localization and Length of Primary Cilia in Principal Neurons in the Cerebral Cortex.

ABSTRACT: The primary cilia of pyramidal neurons in inside-out laminated regions orient predominantly toward the pial surface, reflecting reverse soma re-positioning during postnatal development. However, the mechanisms underlying the directional cilia orientation and reverse movement are unknown. Here we show that the primary cilia of pyramidal neurons are localized near the base of the apical dendrites and aligned on the nuclear side opposite to the axon initial segment. However, this pattern is not observed in atypical pyramidal neurons in the deep neocortex, excitatory neurons in non-laminated brain regions, interneurons, or astrocytes, where their cilia are irregularly positioned around the nuclei and lack preferred orientation. In Reelin-deficient mice (reeler), the directional orientat

SUBMITTER: Akter S 

PROVIDER: S-EPMC12393522 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature