Evolution of Cajal-Retzius Cells in Vertebrates from an Ancient Class of Tp73+ Neurons.

ABSTRACT: In the developing cerebral cortex, Cajal Retzius (CR) cells are early-born neurons that orchestrate the development of mammalian-specific cortical features. However, this cell type has not been conclusively identified in non-mammalian species. Here we studied neurons expressing Tp73, a transcription factor specifically expressed in most mammalian CR cells. Comparisons of chicken, salamander, zebrafish, and little skate data indicate that Tp73-expressing neurons have conserved spatial distribution and transcriptomic signatures in vertebrates. Among the conserved Tp73-expressing cell types we find CR cells andTp73+ external tufted cells (ETCs) in the olfactory bulb of jawed vertebrates. ETCs and CR cells share the expression of most "canonical" CR cell transcription fact

SUBMITTER: Gumnit E 

PROVIDER: S-EPMC12393536 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature