HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.

ABSTRACT: The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched HCN-channel-dependent intrinsic membrane properties and a related sensitivity to synaptic inputs containing delta/theta band frequencies. We tested whether other primate species possess enriched HCN-channel dependent membrane properties. We found ubiquitous HCN1 subunit gene expression in supragranular glutamatergic neurons across New World Monkeys, Old-World Monkeys, and great apes in single nucleus RNA-sequencing datasets. Using Patch-seq recordings from acute and cultured brain slices, we found robust HCN-dependent physiological prop

SUBMITTER: Radaelli C 

PROVIDER: S-EPMC12393543 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature