GCAD: a Computational Framework for Mammalian Genetic Program Computer-Aided Design.

ABSTRACT: Genetic programs can direct living systems to perform diverse, pre-specified functions. As the library of parts available for building such programs continues to expand, computation-guided design is increasingly helpful and necessary. Predictive models aid the challenging design process, but iterative simulation and experimentation are intractable for complex functions. Computer-aided design accelerates this process, but existing tools do not yet capture the behavior of mammalian-specific parts and population-level effects needed for mammalian synthetic biologists. To address these needs, we developed a framework for mammalian genetic program computer-aided design. Starting with a user-defined design specification to quantify circuit performance, the framework uses a genetic algorithm to s

SUBMITTER: Dreyer KS 

PROVIDER: S-EPMC12393561 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature