Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.

ABSTRACT:

Background

Psychological distress has been linked with later cognitive impairment and dementia, although the nature of the association remains unclear. Using a multi-cohort approach, we examined longitudinal associations of psychological distress with subsequent cognition and dementia, testing whether findings varied by age of assessment, severity, and persistence of psychological distress.

Methods

We used five longitudinal studies: Caerphilly Prospective Study, English Longitudinal Study of Ageing, National Child Development Study, National Survey of Health and Development, and Whitehall II. We examined associations with changes in cognition using linear and mixed effects models, and dementia using logistic regression. Results were pooled using two-stage individual particip

SUBMITTER: Stafford J 

PROVIDER: S-EPMC12393618 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature