Effect of smoking on drug-resistant tuberculosis treatment outcomes and exploring potential pathways: A multicountry cohort study.

ABSTRACT: People who smoke are at increased risk of unfavorable tuberculosis (TB) treatment outcomes compared with those who do not, but the pathways explaining this effect are unclear. We estimated the effect of smoking on a successful end-of-treatment outcome for multidrug-resistant and rifampicin-resistant (MDR/RR) TB and examined if intervening on loss to follow-up mitigates this effect. The endTB Observational Study was a prospective cohort of people with MDR/RR-TB who were treated with longer regimens containing bedaquiline and/or delamanid. We used marginal standardization to examine the effect of smoking (≥1 cigarette daily at enrollment) on treatment success (cured/completed). To simulate intervening on lost to follow-up, we censored participants and applied inverse probability of censoring

SUBMITTER: Romo ML 

PROVIDER: S-EPMC12393624 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature