Seasonality and Trends in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Before and During the COVID-19 Pandemic: A Pharmacovigilance Study.

ABSTRACT:

Importance

Seasonal variation in adverse drug reactions has clinical and mechanistic implications for understanding disease mechanisms and risk mitigation strategies. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a life-threatening mucocutaneous reaction with high morbidity and mortality, which may have a seasonal component.

Objective

To determine whether the reporting of SJS/TEN to the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) follows a seasonal pattern, incorporating both traditional seasonal analyses and time-series modeling.

Design

Cross-sectional, population-based analysis of FAERS reports from January 2010 to December 2019. Seasonal differences were assessed using Kruskal-Wallis tests and Seasonal-Trend De

SUBMITTER: Mukherjee EM 

PROVIDER: S-EPMC12393647 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature