The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits.

ABSTRACT: Interactions among brain rhythms play a crucial role in organizing neuronal firing sequences during specific cognitive functions. In memory formation, the coupling between the phase of the theta rhythm and the amplitude of gamma oscillations has been extensively studied in the hippocampus. Prevailing perspectives suggest that the phase of the slower oscillation modulates the fast activity. However, recent metrics, such as Cross-Frequency Directionality (CFD), indicate that these electrophysiological interactions can be bidirectional. Using a computational model, we demonstrate that feedforward inhibition modeled by a theta-modulated ING (Interneuron Network Gamma) mechanism induces fast-to-slow interactions, while feedback inhibition through a theta-modulated PING (Pyramidal Interneuron Ne

SUBMITTER: Chalkiadakis D 

PROVIDER: S-EPMC12393765 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature