INFERRING SYNERGISTIC AND ANTAGONISTIC INTERACTIONS IN MIXTURES OF EXPOSURES.

ABSTRACT: There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together to amplify each other's effects. Such amplification is referred to as synergistic interaction, while chemicals that inhibit each other's effects have antagonistic interactions. Current approaches for assessing the health effects of chemical mixtures do not explicitly consider synergy or antagonism in the modeling, instead focusing on either parametric or unconstrained nonparametric dose response surface modeling. The parametric

SUBMITTER: Chattopadhyay S 

PROVIDER: S-EPMC12393835 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature