Cross-sectional and longitudinal metabolomics-based profiles associated with oral contraceptive and progestin-only pill use: A Finnish population-based study.

ABSTRACT:

Introduction

The use of combined oral contraceptives (COCs), but not of progestin-only pills (POPs) is associated with an increased risk of cardiovascular events. A detailed examination of how different oral contraceptives impact the metabolism in the short- and long-term has not been conducted. This study comparatively examines cross-sectional and longitudinal metabolomics-based profiles of different COCs and POPs, and explores how they perform relative to a metabolically safer contraceptive option.

Material and methods

Data were obtained from a population-based survey (Health 2000) and its 11-year follow-up (Health 2011). Altogether, 212 metabolic measures in OC users (n = 299; COC, n = 245; POP, n = 33) were compared to those in non-users of hormonal contraception (HC; n 

SUBMITTER: Toffol E 

PROVIDER: S-EPMC12393986 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature