Metabolic associations of human placental lactogen in pregnancies at high metabolic risk: An observational cohort study.

ABSTRACT:

Introduction

Human placental lactogen (hPL) is a placental hormone which, according to preclinical research, appears to have key metabolic roles in pregnancy. We aimed to examine pregnancy hPL levels in relation to maternal metabolic parameters and fetal outcomes within an ethnically diverse cohort at high metabolic risk. Design was an observational cohort study, nested within a randomized controlled trial.

Material and methods

Pregnant women (n = 130), recruited for high metabolic risk, underwent measurement of hPL, plus clinical and metabolic parameters, in early pregnancy (15.8 ± 2.5 weeks of gestation). Univariable and multivariable simple linear regression models were used to examine relationships between early pregnancy hPL and key maternal anthropometric and biochemic

SUBMITTER: Rassie K 

PROVIDER: S-EPMC12393997 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature