SHP2 inhibition by SHP099 attenuates IL-6-driven osteoclastogenesis in growth plate injury.

ABSTRACT:

Introduction

Disruption of growth plate cartilage often leads to severe bone growth defects in children, necessitating novel therapeutic strategies. Following growth plate injury, an inflammatory response is rapidly initiated, resulting in the release of pro-inflammatory cytokines such as IL-6 into the injured tissue, which subsequently induce and enhance osteoclast generation and differentiation. This study investigates the role of SHP2 in regulating IL-6-driven osteoclastogenesis during growth plate injury repair.

Methods

Tibial drill-hole injuries were induced in C57BL/6 mice (n=9), with SHP099 (30 mg/kg, intra-articular) administered to intervention groups and tissues were harvested for qPCR/histology. RAW 264.7 cells were treated with RANKL (100 ng/ml) ± IL-6 (100 ng/ml

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12394037 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature