Value of a BRAF^V600E and lymphocyte subset-based nomogram for discriminating benign lesions from papillary thyroid carcinoma in C-TIRADS 3 and higher nodules.

ABSTRACT:

Background

The BRAF^V600E mutation and lymphocyte subsets may be associated with papillary thyroid carcinoma (PTC). This study established and validated a nomogram model to quantitatively predict the malignant risk of papillary thyroid carcinoma in thyroid nodules classified as C-TIRADS category 3 or higher, providing a reference for precise diagnosis and treatment of these moderately or highly suspicious nodules.

Methods

This retrospective study analyzed 210 patients with thyroid nodules (C-TIRADS ≥3), stratified by fine-needle aspiration biopsy (FNAB) results into benign and PTC groups. Clinical and laboratory parameters were systematically collected for all patients. Variable selection was performed using least absolute shrinkage and selection operator (LASSO) r

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12394038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature