DNA methylation and transcription factor-driven immune subtypes in ovarian cancer.

ABSTRACT: Ovarian cancer (OC) remains one of the deadliest gynecological malignancies. Immune checkpoint blockade (ICB) inhibitors efficacy in OC has been minimal, highlighting the need for a deeper understanding of the immune microenvironment in OC. Recent studies suggest that DNA methylation and transcription factors may influence the response to immunotherapy. This study aims to classify ovarian cancer into distinct immune subtypes by integrating DNA methylation and transcription factor data through comprehensive bioinformatics analysis. Using data from The Cancer Genome Atlas (TCGA), we identified twelve differentially methylated genes (DMGs) associated with transcription factors and categorized OC into two immune subtypes, C1 and C2.The C1 subtype exhibited higher levels of immune infiltration

SUBMITTER: Hu J 

PROVIDER: S-EPMC12394097 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature