Disulfidptosis-related LncRNA signatures in gastric cancer: regulation of MYH10-driven cytoskeletal remodeling and therapeutic implications.

ABSTRACT:

Objective

Gastric cancer (GC), a widely recognized malignant neoplasm, poses significant treatment challenges. It is essential to pursue additional research to uncover novel therapeutic approaches and predictive methodologies. The phenomenon of disulfidptosis, recently identified as a distinct type of programmed cell death, offers intriguing possibilities for therapeutic applications.

Method

This study performed differential analysis, GO analysis, KEGG, GSEA, and other analyses to investigate the relationship between disulfidptosis-related LncRNAs (DRLs) and TCGA GC data. The analysis included 373 gastric cancer samples and 32 normal gastric tissue samples, obtained from [specify data source, e.g., TCGA, GEO, or in-house cohorts]. Samples were rigorously screened based on [c

SUBMITTER: Yu J 

PROVIDER: S-EPMC12394114 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature