Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese.

ABSTRACT:

Background

Acute coronary syndrome (ACS) is a critical cardiovascular condition with diverse clinical presentations, necessitating personalized therapeutic approaches. This study explores the genetic variation associated with ACS subtypes in the Han and Uyghur Chinese populations to support the development of precision medicine approaches tailored to ethnic-specific genetic backgrounds.

Methods

A total of 985 ACS patients (668 Han and 317 Uyghur Chinese) representing different ACS subtypes were enrolled. Clinical characteristics and 66 genetic polymorphisms were analyzed. Statistical analyses were conducted to identify differences in genetic variants and clinical features across ACS subtypes and ethnic groups.

Results

Significant clinical and genetic differences were

SUBMITTER: Lai H 

PROVIDER: S-EPMC12394146 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature