Irisin alleviated sepsis via enhancing macrophage phagocytosis and reducing inflammation levels.

ABSTRACT:

Background

The treatment of sepsis relies on antibiotics following infection; however, the emergence of resistant bacteria necessitates the development of new therapeutic agents. Irisin has been shown to alleviate symptoms in septic mice, although its mechanism of action remains unclear. Our aim was to determine the mechanism by which irisin alleviates sepsis.

Methods

In this study, septicemia was induced in mice using Escherichia coli CMCC 44102 (E) and Staphylococcus aureus CMCC 26003 (SA). The level of serum irisin were examined by ELISA kit. Mice with septicemia were intraperitoneally injected with irisin. The survival rate, body temperature, clinical manifestations, body's bacterial load, the number of immune cells in blood, the level of inflammation in th

SUBMITTER: Gong Z 

PROVIDER: S-EPMC12394160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature