Exploring the role of gut probiotic metabolites in the prevention and treatment of otitis media.

ABSTRACT:

Introduction

The gut microbiota derived metabolites show significant therapeutic effects on otitis media, yet the specific active metabolites and mechanisms involved remain undocumented. The primary objective of the study was to utilise a network pharmacology approach to investigate the active metabolites and underlying mechanisms by which gut microbiota exerts their effects against otitis media.

Methods

A set of 110 gut microbiota-derived metabolites was retrieved from the MiMeDB database. Their target genes were identified using SEA (Similarity Ensemble Approach), resulting in 6860 human target genes. Parallelly, a differential expression analysis using the GEO dataset identified dysregulated genes in otitis media. Upon intersecting these with the metabolite target genes,

SUBMITTER: Zheng B 

PROVIDER: S-EPMC12394177 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature