Biomaterials in tissue repair and regeneration: key insights from extracellular matrix biology.

ABSTRACT: The extracellular matrix (ECM) serves as a dynamic biological framework that orchestrates cellular behavior through biomechanical and biochemical cues, playing a pivotal role in tissue homeostasis and repair. Despite significant advancements in biomaterial design, current regenerative strategies often fail to fully replicate the ECM's complexity, leading to suboptimal healing outcomes. This review comprehensively examines ECM biology and its application in biomaterial engineering, highlighting structural-functional relationships, integrin-mediated signaling, and ECM remodeling mechanisms in wound healing. We analyze diverse biomaterial classes-including ECM-based scaffolds, synthetic polymers, natural biomaterials, bioceramics, and composites-focusing on their design principles, fabricatio

SUBMITTER: Abolhasani S 

PROVIDER: S-EPMC12394198 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature