Orally administered extracellular vesicles from <i>Salmonella</i>-infected macrophages confer protective immunity <i>in vivo</i>.

ABSTRACT: Salmonella is a leading cause of foodborne illness in the United States and worldwide. This enteric pathogen deploys various mechanisms to evade the intestinal mucosal barrier to enhance its survival and further infect systemic tissues. Commercially available vaccines against Salmonella are currently restricted to the serovar Typhi, while none are currently approved for non-typhoidal Salmonella (NTS) serovars, which are becoming increasingly resistant to antibiotics. Due to the lack of effective vaccines against NTS infections, novel oral vaccination strategies have garnered significant interest, owing to their protective abilities at the susceptible sites of infection. We previously reported that mice immunized intranasally with small extracellular vesicles (sEVs) der

SUBMITTER: Bhimani S 

PROVIDER: S-EPMC12394216 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature