Tacrolimus Trough Concentrations are Not Impacted by Epstein-Barr Virus Serology and Viral Load in Pediatric Liver Transplant Recipients.

ABSTRACT:

Background and objectives

Epstein-Barr virus (EBV) is a common herpesvirus among pediatric liver transplant recipients, but it can have serious complications, such as post-transplant lymphoproliferative disease. EBV is hypothesized to influence tacrolimus concentrations by increasing inflammatory cytokines that regulate the expression of cytochrome-P-450 enzymes involved in tacrolimus pharmacokinetics. This study aims to examine the association between EBV serostatus and viral load, and tacrolimus trough concentrations corrected for the dose and recipient weight [weight-adjusted concentration-to-dose (C/D) ratios].

Materials and methods

This retrospective study includes pediatric liver transplant recipients aged 0-18 years old, transplanted at the University Medical Center G

SUBMITTER: Te Lintelo AM 

PROVIDER: S-EPMC12394278 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature