The impact of adjuvant radiotherapy on borderline and malignant phyllodes tumors of the breast.

ABSTRACT:

Background

Borderline and malignant phyllodes tumors (PTs) are rare fibroepithelial breast neoplasms associated with a high risk of locoregional recurrence (LRR). Although adjuvant radiation therapy (RT) is increasingly used, its clinical benefit remains uncertain. This study aimed to assess the impact of RT and identify factors associated with LRR in patients with borderline and malignant PTs.

Methods

A retrospective review was conducted on 102 patients (50 borderline, 52 malignant PTs) who underwent surgery between 2012 and 2021. Clinical, pathological, and treatment data were analyzed. The primary endpoint was LRR. Kaplan-Meier and Cox regression models were used to assess recurrence and risk factors.

Results

Median follow-up was 4.3 years. Malignant PTs were more

SUBMITTER: Charoenyothakun A 

PROVIDER: S-EPMC12394283 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature